Genomic transcriptional activity and the structure of chromatin
- 1 April 1976
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 260 (5551) , 495-500
- https://doi.org/10.1038/260495a0
Abstract
Nucleic acid hybridization showed that micrococcal nuclease-derived chromatin subunits from the cells of Xenopus laevis contain fragments of ribosomal 28S, 18S and 5S RNAs within the population of 200 base-pair pieces of DNA. Subunits from cultured embryonic cells actively transcribing ribosomal RNA contain only 70-74% of the cistrons present in undigested wild-type DNA, while subunits from adult erythrocytes not active in RNA transcription contain close to 90% of the ribosomal cistrons in native chromatin.Keywords
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