Evaluation of the 13CO2 kinetics in humans after oral application of sodium bicarbonate as a model for breath testing
- 1 February 1993
- journal article
- clinical trial
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 23 (2) , 91-96
- https://doi.org/10.1111/j.1365-2362.1993.tb00746.x
Abstract
The kinetics of 13CO2 have been investigated following oral administration at five doses between 12.5 and 100 mg of 13C labelled sodium bicarbonate to 10 healthy subjects in a randomized study. Sodium bicarbonate in this study served as a model compound for carbon dioxide/bicarbonate generated in breath tests. Exhalation of 13CO2 into breath was monitored by stable isotope ratio mass spectrometry. The kinetics of 13CO2 were characterized by an apparent terminal elimination half-life of 1 h and a mean recovery of 0.630 of the dose administered. The kinetics were not dose-dependent. These results were in agreement with the findings reported previously after i.v. application of sodium bicarbonate.Keywords
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