Electrolyte-Balance Studies in Normal Volunteers and Clinical Observations on the Effects of Cation-Exchange Resins in Patients with Cardiovascular Disease and in Subjects Receiving Pituitary Adrenocortico-Trophic Hormone (ACTH)

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Abstract
IN 1946 Dock1 suggested that cation-exchange resins might prevent sodium retention. Some of the properties attributed to these resins are consistently found, and meet with common agreement. There are fundamentally two types of cation-exchange resins: carboxylic resins and sulfonic resins functioning in the H+ and NH4 + cycles respectively. Included among the resins that have been studied are Amberlite XE–642, Amberlite XE–662, Amberlite IR–100H, Ionac C–200, Ionac C–284, Permutit XAC3, Dowex 50, Liquonex CRW, Nalcite, Duolite, and Win 3000. During resin therapy, there is a decrease in urinary Na+, K+, Ca++, and Mg++ and . . .