Mechanisms linking obesity to insulin resistance and type 2 diabetes
Top Cited Papers
Open Access
- 13 December 2006
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 444 (7121) , 840-846
- https://doi.org/10.1038/nature05482
Abstract
Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors that are involved in the development of insulin resistance. When insulin resistance is accompanied by dysfunction of pancreatic islet β-cells — the cells that release insulin — failure to control blood glucose levels results. Abnormalities in β-cell function are therefore critical in defining the risk and development of type 2 diabetes. This knowledge is fostering exploration of the molecular and genetic basis of the disease and new approaches to its treatment and prevention.Keywords
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