Influence of dietary fat on fecal mutagenicity in premenopausal women

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Abstract
A dietary intervention study was conducted on 31 premenopausal women (age: 20‐40 years) to investigate the relationship between dietary fat and fecal mutagenicity. After a free‐living period (baseline) of one menstrual cycle, the subjects were placed on a high‐fat diet (40% calories from fat) for 4 menstrual cycles, followed by a low‐fat diet (20% calories from fat) for 4 menstrual cycles. One‐half of the subjects were randomly assigned throughout the study to a diet with a P:S ratio of 1.0 while the other half was assigned to one with a P:S ratio of 0.3; body weight by group remained constant. Threeday stool samples were collected at the mid‐follicular period during the free‐living phase and during the 4th menstrual cycle of each of the 2 controlled diet periods. Mutagenicity was assayed by the SOS chromotest. Reduction of dietary fat was accompanied by a significant decrease in fecal mutagenicity in both P:S groups. Combined values, i. e., both P:S groups, were 20.3 units for high‐fat diets vs. 8.78 for low‐fat diets.

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