Inert Gas Narcosis, the High Pressure Neurological Syndrome, and the Critical Volume Hypothesis
- 6 September 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 185 (4154) , 867-869
- https://doi.org/10.1126/science.185.4154.867
Abstract
The hypothesis that general anesthesia or pressure-induced convulsions occur when a hydrophobic region is expanded or compressed, respectively, by critical amounts is consistent with recent data obtained with mice. Calculations show that anesthesia occurs at an expansion of 1.1 percent and convulsions at a compression of 0.85 percent, the latter site of action being more compressible.Keywords
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