Interaction of antibiotics with functional sites in 16S ribosomal RNA
- 4 June 1987
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 327 (6121) , 389-394
- https://doi.org/10.1038/327389a0
Abstract
Chemical footprinting shows that several classes of antibiotics (streptomycin, tetracycline, spectinomycin, edeine, hygromycin and the neomycins) protect concise sets of highly conserved nucleotides in 16S ribosomal RNA when bound to ribosomes. These findings have strong implications for the mechanism of action of these antibiotics and for the assignment of functions to specific structural features of 16S rRNA.Keywords
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