Relation of Plasma Lipids to Alzheimer Disease and Vascular Dementia

Open Access

1 May 2004

journal article
research article
Published by American Medical Association (AMA) in Archives of Neurology

Vol. 61 (5) , 705-714
https://doi.org/10.1001/archneur.61.5.705

Abstract

The prevalence of dementia is increasing in western societies, and there are no known measures to prevent or cure it. Conflicting data show that dyslipidemia, a modifiable risk factor, is associated with a higher risk of dementia. Reduced high-density lipoprotein cholesterol (HDL-C)¹^,2 and apolipoprotein A-I levels,¹ as well as increased levels of lipoprotein(a),³ have been observed in vascular dementia (VaD) in some but not all studies.⁴^,5 Contradictory results have been found in studies relating total cholesterol,⁶^,7 HDL-C,³^,8^,9 and LDL-C⁶^,8 levels with Alzheimer disease (AD).

Keywords

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