Asymmetric synthesis of (3S)-2,3,4,5-tetrahydropyridazine-3-carboxylic acid

Abstract
The title compound 1a is prepared by a two-step sequence from the cycloadduct 5d, derived from di(tert-butyl) azodicarboxylate and the diene 4b by a hetero Diels-Alder reaction.

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