Mortality and Five Classes of Mouse Immunoglobulins in Early Splenectomy

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Abstract
We studied the effect of early splenectomy on the mortality and on the serum levels of the five classes of immunoglobulins during the first months of life in C3H mice. The mortality observed in newborn splenectomized mice was statistically higher than that observed in normal sham-splenectomized mice. Splenectomy at birth inhibited the normal development of the serum levels of IgM and affected the levels of IgG1; IgG2a, IgG2b and IgA either slightly or not at all.

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