Molecular Features and Functional Constraints in the Evolution of the Mammalian X Chromosome
- 1 January 2005
- journal article
- review article
- Published by Taylor & Francis in Critical Reviews in Biochemistry and Molecular Biology
- Vol. 40 (6) , 313-330
- https://doi.org/10.1080/10409230500356703
Abstract
Recent advances in genomic sequencing of multiple organisms have fostered significant advances in our understanding of the evolution of the sex chromosomes. The integration of this newly available sequence information with functional data has facilitated a considerable refinement of our conceptual framework of the forces driving this evolution. Here we address multiple functional constraints that were encountered in the evolution of the X chromosome and the impact that this evolutionary history has had on its modern behavior.Keywords
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