The Non‐Specific Enhancement of Allergy I.
- 30 April 1983
- Vol. 38 (4) , 239-246
- https://doi.org/10.1111/j.1398-9995.1983.tb01617.x
Abstract
Bordetella pertussis organisms, with or without a small dose of alumhydroxide, enhance in rats the production of IgE antibodies to an unrelated antigen, even if this antigen has been administered 6 weeks beforehand. This non-specific enhancement of IgE antibodies is accompanied by a substantial rise in total serum IgE and by the production of IgE antibodies to B. pertussis. The effect of B. pertussis on IgE synthesis is dose-dependent. No effect of B. pertussis on IgE production can be observed in nude rats.Keywords
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