Adsorption of plasma proteins to DMAA hydrogels obtained by ionizing radiation and its relationship with blood compatibility
- 1 January 1997
- journal article
- Published by Taylor & Francis in Journal of Biomaterials Science, Polymer Edition
- Vol. 8 (5) , 335-347
- https://doi.org/10.1163/156856297x00137
Abstract
The interaction of plasma proteins such as albumin, γ-globulin, and fibrinogen with the surface of graft copolymers DMAA-G-PTFE, DMAA-G-PETFE, and DMAA-G-PE obtained by radiation graft polymerization was studied. The adsorption of serum proteins was affected by the hydrophilicity of the graft copolymers. Increased albumin adsorption and decreased fibrinogen and γ-globulin adsorption with increasing grafting levels was shown. A certain range of degrees of grafting showed an improved blood compatibility of the polymeric surfaces due to the existence of a hydrophilic/hydrophobic balance on the polymers. The results suggest that the DMAA-G-PTFE, DMAA-G-PETFE, and DMAA-G-PE graft copolymers can be used as biomaterials for long-term use in cardiovascular systems.Keywords
This publication has 21 references indexed in Scilit:
- Preparation of125I-Labeled Human Growth Hormone of High Quality Binding Properties Endowed with Long-Term StabilityJournal of Immunoassay, 1989
- Effect of surface texture of grafted films on antithrombogenicityRadiation Physics and Chemistry (1977), 1985
- Radiation grafting of acrylic acid, methacrylic acid and polyfunctional methacrylates onto poly(vinyl chloride)Radiation Physics and Chemistry (1977), 1985
- Morphological foundation of hydrogel use for vascular occlusionDie Makromolekulare Chemie, 1985
- Blood‐compatibility‐water‐content relationships for radiation‐grafted hydrogelsJournal of Polymer Science: Polymer Symposia, 1979
- The role of adsorbed proteins in platelet adhesion onto polymer surfacesJournal of Polymer Science: Polymer Symposia, 1979
- The interaction of polymer surfaces with bloodJournal of Polymer Science: Polymer Symposia, 1979
- INTERACTIONS OF BLOOD AND BLOOD COMPONENTS AT HYDROGEL INTERFACES*Annals of the New York Academy of Sciences, 1977
- Water and hydrogelsJournal of Biomedical Materials Research, 1973
- A new method for evalution of antithrombogenicity of materialsJournal of Biomedical Materials Research, 1972