Sequences in Influenza A Virus PB2 Protein That Determine Productive Infection for an Avian Influenza Virus in Mouse and Human Cell Lines
- 1 June 2001
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 75 (11) , 5410-5415
- https://doi.org/10.1128/jvi.75.11.5410-5415.2001
Abstract
Reverse genetics was used to analyze the host range of two avian influenza viruses which differ in their ability to replicate in mouse and human cells in culture. Engineered viruses carrying sequences encoding amino acids 362 to 581 of PB2 from a host range variant productively infect mouse and human cells.Keywords
This publication has 21 references indexed in Scilit:
- Characterization of an Avian Influenza A (H5N1) Virus Isolated from a Child with a Fatal Respiratory IllnessScience, 1998
- Avian Influenza A Viruses Differ from Human Viruses by Recognition of Sialyloligosaccharides and Gangliosides and by a Higher Conservation of the HA Receptor-Binding SiteVirology, 1997
- Receptor Specificity in Human, Avian, and Equine H2 and H3 Influenza Virus IsolatesVirology, 1994
- The role of RNA segment 1 in an in vitro host restriction occurring in an avian influenza virus mutantVirus Research, 1989
- Differences in the Control of Virus mRNA Splicing during Permissive or Abortive Infection with Influenza A (Fowl Plague) VirusJournal of General Virology, 1984
- Nucleotide sequence of the avian influenza virus A/fowl plague/Rostock/34 segment 1 encoding the PB2 polypeptideVirus Research, 1984
- Influence of the host cell on influenza virus replicationPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1980
- Biosynthesis of the Influenza Virus Envelope in Abortive InfectionJournal of General Virology, 1979
- A single gene determines the host range of influenza virusNature, 1977
- Abortive Infection of L Cells by Fowl Plague Virus: Comparison of RNA and Protein Synthesis in Infected Chick and L CellsJournal of General Virology, 1971