Effects of Alpha-methyldihydroxyphenylalanine, Reserpine and Dihydroxyphenylalanine on Pressor Responses to Norepinephrine and Tyramine in Humans.
- 1 August 1964
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 116 (4) , 1159-1163
- https://doi.org/10.3181/00379727-116-29479
Abstract
Summary The pressor effects of small doses of norepinephrine and tyramine have been studied in normal humans after pre-treatment with therapeutic range doses of methyldopa, reserpine, and DOPA. 1) Methyldopa pretreatment causes an enhanced response to tyramine. 2) Reserpine pretreatment causes a diminished response to tyramine. 3) Methyldopa pretreatment does not affect response to norepinephrine. 4) Reserpine pretreatment causes an enhanced response to norepinephrine. 5) After reserpine, DOPA treatment has no reliable effect on either norepinephrine or tyramine response.Keywords
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