Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator‐activated receptor alpha (PPARα)
Open Access
- 22 March 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (11) , 2284-2288
- https://doi.org/10.1016/j.febslet.2005.03.020
Abstract
This study tests the hypothesis that islet peroxisome proliferator‐activated receptor alpha (PPARα) influences insulin secretion. Freshly isolated islets of normoglycemic PPARα‐null mice display no major alteration of glucose‐stimulated insulin release. However, after 24 h of culture in high glucose, PPARα‐null islets exhibit elevated basal insulin secretion and fail to increase insulin mRNA. 24‐h culture with palmitate replicates this phenotype in wild‐type islets. The data suggest that PPARα is needed to ensure appropriate insulin secretory response in situation of short‐term hyperglycemia, likely by maintaining islet lipid homeostasis. As such, islet PPARα could contribute to delay the progression of type 2 diabetes.Keywords
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