Effects of Chloramphenicol on Incorporation of Glycine-2-C14 into Mammalian Tumor Cell Proteins and Purines.

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Abstract
The effects of 2 of the isomers of chloramphenicol, one the antibiotic, the other inactive toward bacteria, were tested on 2 in vitro systems consisting of mouse ascites tumor cells. In Ehrlich carcinoma cells, the antibiotic isomer inhibited the incorporation of glycine-2-C14 into protein and nucleic acid purines. The other isomer inhibited incorporation into the purines to the same extent, but did not appreciably affect entry into the proteins. In lympho-sarcoma cells, both isomers were equally effective and inhibitions were more pronounced. Incorporation into guanine was inhibited much more than into adenine. This might indicate tumor-inhibiting properties. The levels of the antibiotic necessary to give significant inhibition are much higher than are required to affect bacteria.

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