Glucocorticoid Receptors and Glucocorticoid Resistance in Human Leukemia in Vivo and in Vitro
- 1 January 1986
- book chapter
- Published by Springer Nature
- Vol. 196, 111-127
- https://doi.org/10.1007/978-1-4684-5101-6_8
Abstract
Clinical measurements quantitating glucocorticoid receptor sites in leukemic blasts may give useful prognostic information. In childhood ALL, where the most data is available, “high” receptor content in peripheral or marrow blasts correlated with likelihood of remission on therapy, longer durations of remission and better prognosis generally. In lymphomas and CLL as well, high receptor content correlated with likelihood of response to steroid therapy, though the number of studies is less. In AML the correlation with receptor site content is moot, and in other leukemias the reports are less complete. A model system for childhood ALL is provided by CEM cells, a glucocorticoid sensitive human cell line from a patient with the disease. These cells have glucocorticoid receptors which must be filled by hormone for >24 hr for cell lysis to begin. Four types of glucocorticoid resistance have been identified thus far in clones of these cells. Their distinctive properties are described and their relevance to clinical situations briefly discussed.Keywords
This publication has 32 references indexed in Scilit:
- Molybdate-sensitive and molybdate-resistant activation-labile glucocorticoid-receptor mutants of the human lymphoid cell line CEM-C7The Journal of Steroid Biochemistry and Molecular Biology, 1984
- Role of de novo DNA methylation in the glucocorticoid resistance of a T-lymphoid cell lineNature, 1983
- A new determinant of glucocorticoid sensitivity in lymphoid cell lines.The Journal of cell biology, 1983
- Interferon Production in Human Hematopoietic Cell Lines: Response to Chemicals and Characterization of InterferonsJournal of Interferon Research, 1982
- Hydrocortisone Abrogates Proliferation of T Cells in Autologous Mixed Lymphocyte Reaction by Rendering the Interleukin‐2 Producer T Cells Unresponsive to Interleukin‐1 and Unable to Synthesize the T‐Cell Growth FactorScandinavian Journal of Immunology, 1982
- Glucocorticoid receptors and sensitivity in leukemiasAnnals of Hematology, 1981
- Unlinked control of multiple glucocorticoid-induced processes in HTC cellsMolecular and Cellular Endocrinology, 1979
- Dexamethasone induces irreversible G1 arrest and death of a human lymphoid cell lineJournal of Cellular Physiology, 1979
- Characterization of two forms of glucocorticoid hormone-receptor complex separated by DEAE-cellulose column chromatographyBiochemical and Biophysical Research Communications, 1977
- Predinsome therapy of acute childhood leukemia: Prognosis and duration of response in 330 treated patientsThe Journal of Pediatrics, 1967