The Effect of Phosphorus32, Dextran, Reserpine and Stypturon on Thrombus Formation in Rats

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Abstract
The effect of the radioisotope P32, hydrolysed dextran, reserpine, stypturon on thrombus formation was determined by injecting these substances into rats before a standardized operation on the jugular vein. 5 hours after the operation 65% of control animals showed a thrombus. 10 days after intravenous injection of 2, 3, or 4 µC/g, the incidence of thrombosis was lowered in direct relation with the reduced platelet counts varying from 65% incidence for counts above 200 000/mm3 to 0% incidence for counts less than 38 000/mm3. Animals injected with dextran, 2 hours, or reserpine, 48 hours before the operation had an incidence of thrombosis of 48% (P * Contribution from the Department of Physiology and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan. This investigation was aided by the Saskatchewan Heart Foundation. ** Research Associate of the National Heart Foundation of Canada.