INCREASE IN RAT BRAIN TYROSINE HYDROXYLASE ACTIVITY PRODUCED BY ELECTROCONVULSIVE SHOCK
- 1 August 1969
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 63 (4) , 1117-1119
- https://doi.org/10.1073/pnas.63.4.1117
Abstract
A sustained increase in the turnover of norepinephrine coupled with an increased concentration of that amine has, in a previous study, been observed in the brains of rats exposed to electroconvulsive shock twice daily for one week. The phenomenon has been further examined by studying the effects of a similar regimen of electroconvulsive shock upon tyrosine hydroxylase in the brain, since that enzyme appears to be rate-limiting in norepinephrine synthesis. A small (15%) but significant increase in the whole brain enzyme activity was found in the electroshock-treated animals. A significant increase of tyrosine hydroxylase activity was found in the brainstem (24%) and cortex (20%) of such animals.Keywords
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