EFFECTS OF KETAMINE ON BRAIN MONO-AMINE LEVELS IN RATS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 20  (3) , 475-488
Abstract
The effects of ketamine (50 mg/kg i.p.) on brain monoamines, including epinephrine, norepinephrine, dopamine, serotonin and its metabolite 5-hydroxy indoleacetic acid, were studied in 3 groups of male Sprague-Dawley rats. A rapid, simple, accurate and sensitive spectrophotoflurometric method was developed to determine monoamines extracted from rat brain. Ketamine significantly increased brain epinephrine (25%), serotonin (28%) and 5-hydroxy indoleacetic acid (32%) in rats. Norepinephrine (43%) and dopamine (58%) levels were significantly reduced at 30 min. The increase in epinephrine (13%) and decrease in norepinephrine (31%) and dopamine (38%) levels remained significant 12 h after ketamine injection. Serotonin and 5-hydroxy indoleacetic acid levels returned to almost normal in ketamine pretreated animals after 12 h. The ability of ketamine to interfere with monoamine metabolism was revealed.

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