Toxicity of Bunamidine

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Abstract
Extract Sudden death after routine dosing of dogs with the anthelmintic, bunamidine, is probably due to the onset of ventricular fibrillation (Fastier et al., 1968 Fastier, F. N. , Menrath, R. L. E. , Ng, J. and Sharard, A. 1968. Induction of ventricular fibrillation with adrenaline in dogs pretreated with bunamidine hydrochloride. Proc. Univ. Otago med. Sch., 46: 64–66. [Google Scholar] ). However, it has not proved possible to discover conditions under which ventricular fibrillation can be obtained consistently in dogs by treatment with bunamidine and adrenaline. This makes it difficult to test in dogs what was thought would be a reasonable prophylactic measure, namely, administration of a beta-blocker. Treatment with such beta-blockers as propranolol has been found to reduce substantially the occurrence of ventricular arrhythmias in circumstances where sympathetic activity plays an important part in the initiation of the disorder (Lucchesi and Whitsitt, 1969 Lucchesi, B. R. and Whitsitt, L. S. 1969. The pharmacology of beta-adrenergic blocking agents. Prog. cardiovasc. Dis., 11: 410–430. [Google Scholar] ; Dollery et al, 1969 Dollery, C. T. , Paterson, J. W. and Conolly, M. E. 1969. Clinical pharmacology of beta-receptor-blocking drugs. Clin. Pharmacol. Therap., 10: 765–799. [Google Scholar] ).

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