Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes. Kinetics and sensitivity to cytochrome P450 2D inhibitors
Open Access
- 1 September 2003
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 270 (18) , 3768-3777
- https://doi.org/10.1046/j.1432-1033.2003.03763.x
Abstract
No abstract availableKeywords
This publication has 35 references indexed in Scilit:
- Homology Modeling of Rat and Human Cytochrome P450 2D (CYP2D) Isoforms and Computational Rationalization of Experimental Ligand-Binding SpecificitiesJournal of Medicinal Chemistry, 2002
- Cryopreserved human hepatocytes: characterization of drug-metabolizing activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug–drug interaction potentialChemico-Biological Interactions, 1999
- Contribution of human hepatic cytochrome P450s and steroidogenic CYP17 to the N-demethylation of aminopyrineXenobiotica, 1999
- Inhibition and Induction of Cytochrome P450 and the Clinical ImplicationsClinical Pharmacokinetics, 1998
- Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic InteractionsClinical Pharmacokinetics, 1997
- Genomic Cloning and Protein Expression of a Novel Rat Brain Cytochrome P-450 CYP2D18* Catalyzing Imipramine N-DemethylationPublished by Elsevier ,1996
- Uptake of organic anions by isolated rat hepatocytes: A classification in terms of ATP-dependencyJournal of Hepatology, 1992
- Primary culture of adult rat hepatocytes after 48-hour preservation of the liver with cold UW solutionHepatology, 1990
- Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitorsXenobiotica, 1990
- Drug Oxidations Dependent on Cytochrome P‐450 in Isolated HepatocytesEuropean Journal of Biochemistry, 1977