Muscle hypertrophy after partial denervation: a human case.

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Abstract
While undergoing long-term physiotherapy, a 41 yr old woman with a chronic S1 radiculopathy developed progressive, painless enlargement of the weak calf. Gastrocnemius muscle biopsy disclosed changes of partial denervation and reinnervation, with small groups of type I and type II atrophic muscle fibers and abundant hypertrophic fibers of both types but mostly type II. It is postulated that, in addition to compensatory work-induced type II muscle fibre hypertrophy, there was an element of (type I) stretched-induced hypertrophy of denervated fibers, a condition well recognized experimentally but not documented in man.