Clinical and Laboratory Evaluation of a New Inhalation Agent: Compound 347 (CHF2-O-CF2-CHF Cl)

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Abstract
Compound 347 (CHF2-O-CF2-CHFCI), a new non-explosive, fluorinated ether, was administered with nitrous oxide-oxgen to 100 patients for major elective abdominal operations. This agent provided rapid, pleasant induction and emergence and adequate hypnosis, analgesia and muscular relaxation, with minimal alterations in the vital signs. Circulatory dynamics and cardiac rhythm remained relatively stable. Patient acceptance was excellent. Comprehensive laboratory studies of the blood showed no change in acid-base balance, serum Na and Cl, a slight decrease of serum K and inorganic P, a marked increase in blood glucose and plasma cortisol, no change in histamine or serotonin, 5-hydroxytryptamine and an increase in plasma catecholamines. Transaminases (SGOT [serum glutamic oxalacetic transaminase], and SGPT) [serum glutamic pyruvic trans-amine] rose slightly, while there was no change in the blood urea N of creatinine. This anesthetic deserves clinical evaluation.

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