ACNEFORM ERUPTION ON AN INFANT AFTER ANTEPARTUM AND NEONATAL CORTISONE THERAPY

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Abstract
Many drugs are known to cross the placenta and to exert an influence on the fetus. Cortisone appears to be capable of crossing the placenta, and it has been used in an effort to minimize or prevent the effects of erythroblastosis fetalis. Pregnant Rh-negative women who had previously given birth to erythroblastotic babies were given oral cortisone at about the 28th week of pregnancy.1 In one instance, it appears that cortisone thus administered might have caused a generalized acneform eruption on a newborn infant. The mother had received 100 mg. of cortisone daily for two months immediately prior to delivery. The infant was given 75 mg. of cortisone the first day and 50 mg. the second. A generalized acneform eruption developed, characterized essentially by the appearance of numerous superficial pustules. The cortisone therapy was discontinued, and penicillin and streptomycin were administered. The eruption disappeared entirely within three or

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