Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism.

  • 1 June 1994
    • journal article
    • Vol. 317  (6) , 499-503
Abstract
To assess the possibility that lipopolysaccharide (LPS) induces sickness behaviour by activating primary afferent nerves, the effects of LPS (1.25 mg kg-1, intraperitoneally) were compared in vagotomized and sham-operated rats. Subdiaphragmatic vagotomy blocked the LPS-induced depression of social investigation but had no effect on LPS-induced increases in levels of IL-1 beta in plasma and peritoneal macrophages and on LPS-induced changes in dehydrogenase activity of peritoneal macrophages.

This publication has 0 references indexed in Scilit: