Mycophenolic acid in the treatment of psoriasis: long-term administration

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Abstract
Thirty five patients with psoriasis (plaque type 26, guttate 3, pustular 4, and erythrodermic 2) were treated with oral mycophenolic acid for a period ranging from 52-104 wk. The average follow-up was 89 wk, and the dose schedule ranged from 2400-7200 mg daily. Excellent response was noted in 20 patients, good in 13 patients, and poor in 2. The most common clinical side effects were in the gastrointestinal tract, namely, diarrhea, nausea, abdominal cramps and soft stools. A high incidence of herpes simplex, herpes zoster and a flu-like syndrome was noted. Laboratory abnormalities consisted of mild blood Hb reduction, 1 case of leukopenia (3900 WBC [white blood cells]/mm3), 2 cases with thrombocytopenia and mild elevation of alkaline phosphatase. Mycophenolic acid appears as a promising drug for the treatment of severe psoriasis.

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