HLA-DR AND MT ASSOCIATIONS WITH THE CLINICAL AND SEROLOGIC MANIFESTATIONS OF PAUCIARTICULAR ONSET JUVENILE RHEUMATOID-ARTHRITIS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 12  (1) , 114-118
Abstract
Significant HLA-DR and MT associations were observed with certain clinical and serologic manifestations of pauciarticular onset juvenile rheumatoid arthritis (PO-JRA). An increase in the MTI frequency was found in 56 children with PO-JRA in comparison to 95 normal controls. This association was limited to children with a younger age of onset (< 6 yr) and a persistent pauciarticular course. An increase in HLA-DRW8 and a decrease in DR4 were associated with a younger age of onset and antinuclear antibody (ANA) seropositivity. An increased frequency of DR5 was seen in ANA positive children. All of these HLA-DR and MT associations were independent of coassociating Ia specificities.