HYPOPHYSEAL AND ADRENAL INFLUENCE ON RENAL FUNCTION IN THE RAT

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Abstract
Hypophysectomy in the rat resulted in an immediate polyuria and polydipsia (80% of cases) which subsided after 4 to 6 days. Following simultaneous removal of the pituitary and adrenal glands no such effects were observed. This was interpreted as evidence of the antagonistic action of the secretions of the post. pituitary lobe and the adrenal cortex on fluid metabolism. In all cases, hypophysectomy, adrenalectomy, and hypophyso-adrenalectomy resulted in reduction of urinary chloride content. Conc. to abnormally high levels occurred a few days later. Injs. of post-pituitary soln. into hypophysectomized or adrenalectomized rats prevented the reduction of urinary chloride conc. This material was effective in raising the urinary chloride content 2 or 3 times above the normal value in such operated animals. Cortico-adrenal extract adm. failed to prevent hypochloruria in hypophysectomized rats, but was effective on adrenalectomized animals. Lack or deficiency of the post-pituitary hormone apparently explained the hypochloruria following hypophysectomy or adrenalectomy. The results indicated a primary or direct involvement of the post-pituitary (or hypothalamic) mechanism in the regulation of salt and fluid balance of the body. An apparently indirect action on salt metabolism through the adrenal cortex was also demonstrated.

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