Characterization of a canine adenovirus hemagglutinin

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Abstract
The hemagglutinating activity of the canine adenoviruses was found to be more than 80% associated with both the intact and incomplete ('empty') virus particles, the remaining complete hemagglutinating activity being associated with a naturally occurring soluble penton dimer structure. Trypsin treatment of the hemagglutinin – red blood cell complex and receptor-competition experiments, using purified fiber component to block the receptor sites on the red blood cells, indicate that there are different receptors for infectious canine laryngotracheitis (ICL) virus and infectious canine hepatitis (ICH) virus.The ICL adenovirus was found to hemagglutinate human and rat erythrocytes but not those of a number of other animal species. Using human group 'O' erythrocytes the ICL virus associated hemagglutinating activity was found to occur over a wide range in temperature and pH, and certain purification procedures, such as fluorocarbon treatment and sonic oscillation, were found to inactivate the hemagglutinin rapidly.

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