Schwann Cells as Antineuroblastoma Agents

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Abstract
Neuroblastoma is the most enigmatic of neoplasms of children because of its variable clinical behavior: it may regress spontaneously in infants, mature into a benign ganglioneuroma in older patients, or grow relentlessly and be rapidly fatal.1 Neuroblastomas are also heterogeneous histopathologically, with a spectrum ranging from the most undifferentiated neuroblastomas to fully mature, benign ganglioneuromas. Tumors in intermediate stages of differentiation are referred to as ganglioneuroblastomas. Three notable changes occur during the progression from primitive neuroblastoma to differentiated ganglioneuroma: neuroblasts mature and come to resemble ganglion cells, the number of mitotic or karyorrhectic (dying) cells decreases, and much of the . . .