Synergistic Effects of the Alkaloid Sinomenine in Combination with the Immunosuppressive Drugs Tacrolimus and Mycophenolic Acid**
- 1 February 1999
- journal article
- letter
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 65 (01) , 80-82
- https://doi.org/10.1055/s-2006-960446
Abstract
The alkaloid Sinomenine extracted from the medicinal plant Sinomenium acutum is used in China for the treatment of various rheumatic diseases. It has immunomodulatory properties in a cardiac allograft transplantation model. Its antiproliferative effect on human mononuclear cells in combination with different immunosuppressive drugs was further analysed in vitro. Sinomenine dose-dependently attenuated thymidine incorporation, interleukin-2 synthesis, and cell cycle progression of activated T-lymphocytes. Cell proliferation was synergistically decreased by addition of Sinomenine together with sub-optimal concentrations of the established immunosuppressive drugs tacrolimus or mycophenolic acid, respectively.Keywords
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