Reduced myocardial actomyosin adenosine triphosphatase activity in the ageing male Fischer rat

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Abstract
Actomyosin was extracted from myocardial homogenates from male rats of different ages of a long-inbred Fischer rat colony maintained under controlled conditions of temperature, humidity and light. ATPase specific activity rose to a maximum at 2 mo. of age; this was followed by a progressive decline by about 25% at 16 mo. of age. The extractable actomyosin remained constant during this period. This loss in actomyosin ATPase specific activity is in good agreement with previously reported decrements in stroke index and myocardial Ca content and an increase in myocardial contraction duration in aged rats.