AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer
- 1 November 1995
- journal article
- research article
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 14 (3) , 220-222
- https://doi.org/10.1002/gcc.2870140311
Abstract
Chromosome 6 has been shown to contain at band q27 a minimal region of deletion associated with epithelial ovarian cancers and AF6, a gene disrupted in acute myeloid leukemia with t(6;11)(q27;q23). Using rapid amplification of cDNA ends by polymerase chain reaction, the breakpoint in AF6 was confirmed and a cDNA clone identified. This clone was used as a probe to screen a chromosome 6 cosmid library, and a single cosmid C‐109F0645 was isolated. By fluorescence in situ hybridization, C‐109F0465 was found to map distal to the critically deleted region associated with ovarian malignancies. AF6 is therefore distinct from and lies telomeric to this region.Keywords
This publication has 12 references indexed in Scilit:
- A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemiaBlood, 1995
- Construction of cosmid libraries from flow-sorted human chromosomes 1, 6, 7, 11, 13, and 18 for reference library resourcesMammalian Genome, 1994
- Common region of deletion on the long arm of chromosome 6 in non‐Hodgkin's lymphoma and acute lymphoblastic leukaemiaGenes, Chromosomes and Cancer, 1994
- Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemiaGenes, Chromosomes and Cancer, 1994
- Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.Proceedings of the National Academy of Sciences, 1993
- Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.Proceedings of the National Academy of Sciences, 1993
- A Genetic Linkage Map with 16 RFLP Loci on the Distal Long Arm of Human Chromosome 6Genomics, 1993
- The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 geneCell, 1992
- Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemiasCell, 1992
- The der(II) chromosome contains the critical breakpoint junction in the 4;11, 9;11, and 11;19 translocations in acute leukemiaGenes, Chromosomes and Cancer, 1992