Diagnosis of Pleural Tuberculosis by Detection of Specific IgG Anti-Antigen 60 in Serum and Pleural Fluid

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Abstract
The objective of this study was the prospective evaluation of the IgG antibody levels to mycobacterial antigen 60 (A60) in serum and pleural fluid and their role in the diagnosis of tuberculous pleuritis. The level of IgG was measured by Elisa in 30 patients with tuberculous pleuritis and 48 control subjects with pleural effusion (24 with carcinoma, f 0 with transudative pleural effusion, 11 with empyema or parapneumonic effusion, 1 with pulmonary embolism and 2 due to systemic lupus erythematosus). The median titers of IgG against A60 of both serum and pleural fluid from tuberculous patients [445.6 ± 133.56 and 263 ± 72.58 Elisa units (EU) respectively] were significantly higher than those of corresponding median values (97.3 ± 8.35 and 41.3 ± 4.93 EU) of the control group (p

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