Dialysis Studies in Rats on the Long-Acting Antimalarial CI-501
- 23 August 1963
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 141 (3582) , 723-725
- https://doi.org/10.1126/science.141.3582.723
Abstract
Through the use of dialysis sacks, containing the repository antimalarial CI-501, implanted intraperitoneally into rats, evidence has been obtained indicating a local rather than a systemic reservoir of the drug. These results suggest that the repository activity of CI-501 is due to drug release from the injection site and that the probability of toxic effects resulting from storage or accumulation of the drug in vital organs is remote.Keywords
This publication has 4 references indexed in Scilit:
- The Effect of a Repository Preparation of the Dihydrotriazine Metabolite of Chlorguanide, CI-501, Against the Chesson Strain of Plasmodium Vivax in ManThe American Journal of Tropical Medicine and Hygiene, 1963
- The Activity of a Repository Form of 4,6-Diamino-1-(p-Chlorophenyl)-1,2-Dihydro-2,2-Dimethyl-s-Triazine against Infections with Plasmodium CynomolgiThe American Journal of Tropical Medicine and Hygiene, 1963
- Laboratory Studies on 4,6-Diamino-1-(p-Chlorophenyl)-1,2-Dihydro-2,2-Dimethyl-s-Triazine Pamoate (CI-501) as a Repository Antimalarial DrugThe American Journal of Tropical Medicine and Hygiene, 1963
- “ANTRYCIDE”*—A NEW TRYPANOCIDAL DRUGBritish Journal of Pharmacology and Chemotherapy, 1950