Synthesis of sequential polydepsipeptides involving depsipeptide formation by the 2-nitrophenylsulphenyl N-carboxy α-amino acid anhydride (Nps–NCA) method
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 10,p. 2249-2251
- https://doi.org/10.1039/p19870002249
Abstract
Sequential polydepsipeptides containing a tripeptide sequence Ala-Ala-Glu(OEt) and various α-hydroxy acids have been successfully prepared by polycondensation of tetradepsipeptide pentachlorophenyl esters. The latter were synthesized by preparation of didepsipeptide free acids by the Nps-NCA method followed by active esterification and peptide chain elongation by the so-called ‘back-up’ procedure.Keywords
This publication has 0 references indexed in Scilit: