Microbial cleavage of zearalenone
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 18 (4) , 365-371
- https://doi.org/10.3109/00498258809041672
Abstract
1. Zearalenone, a fungal oestrogenic compound, was subjected to microbial transformation studies. Preliminary screening with 150 fungal species showed that Gliocladium roseum was capable of metabolizing zearalenone in 80-90% yields. 2. Large-scale fermentation with G. roseum produced a 1:1 mixture of 1-(3,5-dihydroxyphenyl)-10′-hydroxy-1-undecen-6′-one and 1-(3,5-dihydroxyphenyl)-6′-hydroxy-1-undecen-10′-one. The compounds were isolated and purified at −20°C. and identified using spectroscopic analysis and by comparison to products obtained from alkaline hydrolysis of zearalenone.This publication has 15 references indexed in Scilit:
- Microbial Transformation of Zearalenone, I. Formation of Zearalenone-4-O-β-glucosideJournal of Natural Products, 1987
- Zeranol—A ‘nature-identical’ oestrogen?Food and Chemical Toxicology, 1985
- Microbial models of mammalian metabolism: stereospecificity of ketone reduction with pentoxifyllineXenobiotica, 1985
- Metabolism of Zearalenone in Rat LiverActa Pharmacologica et Toxicologica, 1978
- Microbial Models of Mammalian MetabolismJournal of Pharmaceutical Sciences, 1975
- Microbial systems for study of the biotransformations of drugsBiotechnology & Bioengineering, 1975
- Chemistry of Zearalenone and Some of Its DerivativesHETEROCYCLES, 1975
- Microbial models of mammalian metabolism. Aromatic hydroxylationArchives of Biochemistry and Biophysics, 1974
- Total synthesis of the macrolide, zearalenoneTetrahedron, 1968
- The structure of zearalenoneTetrahedron Letters, 1966