The object of this report is so to relate the observations made in connection with a number of cases of systemic blastomycosis that a better understanding may obtain of the disease not only in this locality, where clinicians are already quite familiar with it, but also in places where it has been encountered but rarely or not at all. Two summaries of the literature have already been made, that by Hektoen1dealing with thirteen cases, and the one by Montgomery and Ormsby2with twenty-two. The second of these reviews contains brief accounts of the illnesses of four patients in this series and the post-mortem examinations on the bodies of two of them. The other two patients have since died and we are able to add the more detailed clinical records and the final results of the studies of material from two additional post-mortem examinations. On account of the