ENZYMATIC ASSAY FOR THE ANTI-TUMOR AGENT N-(PHOSPHONACETYL)-L-ASPARTIC ACID (PALA)

  • 1 January 1979
    • journal article
    • research article
    • Vol. 63  (1) , 85-88
Abstract
A method is described for the assay of PALA [a potential antineoplastic drug] in plasma or urine, based on inhibition of partially purified aspartate carbamoyltransferase [EC 2.1.3.2] from rat liver. Concentrations of PALA as low as 0.1 .mu.g/ml can be detected. Plasma disappearance and urinary excretion curves from 1 patient are shown as examples of the application of the method.

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