BILATERAL SUBTOTAL ADRENALECTOMY FOR CUSHING'S SYNDROME

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Abstract
Patients (6) with Cushing''s syndrome due to adrenal hyperplasia were treated with subtotal bilateral adrenalectomy, performed in 2 stages at an interval of 2 - 4 months. Nine-tenths of both adrenals were removed. In one case complete adrenalectomy was performed on one side and a partial adrenalectomy on the other, 3/4 of the gland being removed. This was the only case with slight signs of recurrence 18 months after operation. In each case most of the symptoms typical of the syndrome disappeared. Three of the 5 female patients regained their menstrual periods, one became pregnant. In no case were there signs of adrenal insufficiency, but in one case there was marked darkening of the skin, probably due to hypophyseal overactivity. One patient died of an infectious disease 4 months after operation.

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