Sensitivity of antiproteases, complement factors and C-reactive protein in detecting pancreatic necrosis. Results of a prospective clinical study

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Abstract
Summary Thirty-five patients with acute pancreatitis underwent serum monitoring of α-1-protease inhibitor, α-2-macroglobulin, complement factors C3+C4, and C-reactive protein (CRP). Edematous interstitial pancreatitis was shown to be present in 13 patients by contrast-enhanced computed tomography (CT) and laparotomy (n=3). Necrotizing pancreatitis was confirmed by laparotomy (n=21) and contrast-enhanced CT. There were significant differences between the serum values of all measured parameters in the two morphologically defined pancreatitis groups. The best discriminating factors were CRP and α-2-macroglobulin, showing 95% and 85% overall detection rates for pancreatic necrosis, respectively.