Attempts to Produce Acute Cardiac Failure by Posterior Pituitary Extracts

Publisher Website
Google Scholar
Abstract
An attempt was made to reduplicate clinical conditions in which a depressed left ventircle with a reduced coronary flow is required to work against high arterial pressures (a) by repeated or continuous infusions of post, pituitary extracts, and (b) by creating additional arterial resistance through cutting of afferent moderator nerves or mechanical compression of the aorta. In all of these ways, it proved impossible over periods of 3-4 hrs. to induce a state comparable to clinical congestive heart failure. If such failure is secondary to left ventricular strain plus reduction of coronary flow and myocardial depression, the time element must play a dominant role. Additional information regarding the nature of left ventricular depression induced by large doses of post, pituitary extracts was obtained by an analysis of the aortic pressure pulses. Exptl. evidence indicated that serious cardiac consequences are not apt to result from use of post, pituitary prepns. administered to patients with normal hearts in therapeutic doses.

This publication has 2 references indexed in Scilit: