Coincident Classic Hemophilia and Idiopathic Thrombocytopenic Purpura in Patients under Treatment with Concentrates of Antihemophilic Factor (Factor VIII)

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Abstract
Home treatment of classic hemophilia with lyophilized concentrates of antihemophilic factor (factor VIII) is now widely practiced. We studied a syndrome resembling chronic idiopathic thrombocytopenic purpura in five patients with severe classic hemophilia who were receiving such therapy. Laboratory studies are summarized in Tables 1 through 3. The presence of increased amounts of platelet-associated IgG, the favorable response in four patients treated with prednisone, and remission after splenectomy in one patient all suggest that the patients' disorder resembled idiopathic thrombocytopenic purpura. In addition, studies in four patients demonstrated evidence of impaired cell-mediated immunity in three.Case ReportsPatient 1A 21-year-old . . .