Trisomic Hemopoietic Stem Cells of Fetal Origin Restore Hemopoiesis in Lethally Irradiated Mice
- 13 March 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 211 (4487) , 1175-1177
- https://doi.org/10.1126/science.7466390
Abstract
Autosomal trisomy in the mouse is invariably associated with fetal or early postnatal death. Hemopoietic stem cells from fetuses trisomic for chromosome 12 or 19 can be rescued by transplantation into lethally irradiated mice. These trisomic cells restore hemopoiesis, including lymphopoiesis, in the irradiated mice and establish a permanent and almost complete engraftment. There is no evidence that hemopoietic cells with trisomy 12 or 19 are cytogenetically unstable.This publication has 6 references indexed in Scilit:
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