Oligomeric organization of gp120 on infectious human immunodeficiency virus type 1 particles
- 1 November 1990
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 64 (11) , 5674-5677
- https://doi.org/10.1128/jvi.64.11.5674-5677.1990
Abstract
The oligomeric structure of the human immunodeficiency virus type 1 envelope glycoprotein (gp120) was examined by treating infectious virions with chemical cross-linking agents and subjecting the protein to sodium dodecyl sulfate-polyacrylamide gel electrophoresis and velocity centrifugation. Immunoblots of cross-linked samples revealed three gp120 bands and an approximately threefold shift in gp120 sedimentation. Our finding of cross-linking solely between gp120 suggests that the gp120 subunits are closely associated in the native envelope structure.This publication has 17 references indexed in Scilit:
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