Influence of Parasympathetic Innervation on the Volume of Pancreatic Juice

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Abstract
Atropiae, ganglionic blocking agents and acute or chronic interruption of the vagi reduced the pancreatic response to intravenous secretin in chronic external pancreatic fistula dogs. Analysis of secretin dosage-response curves before and after atropine supports the conclusion that this drug depresses the sensitivity of the gland to secretin. After chronic vagal section, atropine and a ganglionic blocking agent no longer significantly depress the response to secretin. These results are consistent with the view that the parasympathetic innervation of the pancreas, by virtue of the liberation of acetylcholine at its endings, sensitizes the gland to secretin. Vagal block or ganglionic block lowers the protein content of the secretin stimulated juice.