Antigenic relationships among proteins of bovine coronavirus, human respiratory coronavirus OC43, and mouse hepatitis coronavirus A59

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Abstract
Antisera prepared against each of 3 single and 1 pair of major structural proteins of the bovine coronavirus (Mebus strain) were used in immunoblotting studies to measure cross-reactivity with the structural proteins of the human coronavirus OC43 and the mouse hepatitis coronavirus A59. The bovine coronavirus is comprised of 4 major structural proteins, gp190 (normally present as 120- and 100-kilodalton subunits), gp140, pp52 and gp26. The human coronavirus OC43 has an antigenically homologous counterpart of similar molecular mass to each of these proteins. The mouse hepatitis coronavirus A59 has an antigenically homologous counterpart to only 3 of these proteins: gp190, pp52 and gp26. There is no counterpart in the mouse virus to gp140, the apparent hemagglutinin of the bovine coronavirus.