Erythromycin in the Treatment of Early Syphilis
- 1 August 1959
- journal article
- research article
- Published by American Medical Association (AMA) in A.M.A. Archives of Dermatology
- Vol. 80 (2) , 205-209
- https://doi.org/10.1001/archderm.1959.01560200073009
Abstract
In 1953, Keller and Morton1first reported on the treponemicidal properties of erythromycin in vitro, utilizing a variety of treponemal strains. They reported cultivatable treponema to be very susceptible to the action of erythromycin. The following year, Turner and Schaeffer2confirmed their report by comparing the effectiveness of various antibiotics in experimental rabbit syphilis. They found Treponema pallidum more sensitive to erythromycin and carbomycin than to any of the other antibiotics except penicillin and suggested further therapeutic trials. On the other hand, Kolmer3in a similar comparative study reported both oxytetracycline and tetracycline superior to erythromycin in treponemicidal properties. In 1954, Alexander and Schoch4reported on four patients with early syphilis treated with 200 mg. of oral erythromycin four times daily for eight days (total dose of 6.4 gm.). T. pallidum disappeared from the lesions in 24 to 30 hours,Keywords
This publication has 0 references indexed in Scilit: